"Since the establishment of diplomatic relations 45 years ago, the relationship between the two countries has grown into a towering tree, bearing the fruit of cooperation, which has benefited both countries and the world." On January 4th, the Supreme Leader of president wrote back to Sarah Landy, a friend from Iowa, USA, stressing that China and the United States are the largest developing countries and developed countries in the world, and the future and destiny of this planet need Sino-US relations to be stabilized and improved. American friendly people interviewed by this reporter said that on the occasion of commemorating the 45th anniversary of the establishment of diplomatic relations between China and the United States, the Chairman of the Supreme Leader wrote back to American friends and once again invited American teenagers to exchange and study in China, which injected confidence into the friendly exchanges between the two countries and added impetus to the stable, healthy and sustainable development of bilateral relations.

　　 "The development of US-China relations is the result of the joint participation of the two peoples."

　　Recently, Sarah Landy, a friend from Iowa, USA, wrote to the Chairman of the Supreme Leader, saying that the speech made by the Chairman of the Supreme Leader at the welcome banquet jointly held by American friendship groups was very popular and inspiring, and it was exciting to invite 50,000 American teenagers to exchange and study in China in the next five years. I hope Muscatine High School will also participate in this plan. As big countries, the United States and China should work together to solve problems including climate change, food security, drugs and regional conflicts for the benefit of human society.

　　"I am very excited and honored to receive the reply from the Chairman of the Supreme Leader. I am very grateful to the Chairman of the Supreme Leader for caring about the old friends in Iowa, caring about the development of Muscatine, and caring about the friendly exchanges between the US and Chinese people. " In an interview with this reporter, the 85-year-old Landy said, "Last November, the Chairman of the Supreme Leader attended the joint welcome banquet of American friendship groups in San Francisco and delivered an important speech, vividly telling the history of Sino-US friendly exchanges and conveying very important information. I hope to do my part to promote the friendship between the US and China, and I hope that the people of Muscatine will have more exchanges with the people of China. "

　　In 1985, Landy received the top leader of Zhengding County Party Committee in Hebei Province to visit Muscatine. In 2012, during the visit of the then Vice President and Supreme Leader to the United States, he went to Landy’s home again to meet with old American friends. In 2022, Landy sent a letter to the Chairman of the Supreme Leader, thanking President Xi for his precious friendship with his old friends, and looking forward to further deepening people-to-people exchanges and enhancing mutual understanding and trust between the two countries. Chairman of the Supreme Leader wrote back to Landy at that time, encouraging her and her old friends in Iowa to continue to sow the seeds of friendship and make new contributions to the friendship between the Chinese and American peoples.

　　Randy said with personal experience: "Any form of communication is not as good as face-to-face communication. I hope that students from Muscatine High School can visit China, learn about the history of China, appreciate the ancient buildings in China, experience the modern infrastructure in China, have extensive exchanges with friends from China and study the development experience of China. Although there are many differences between the United States and China, by strengthening exchanges and communication, young people of the two countries can broaden their horizons, enhance understanding, know how to respect each other and cooperate more easily. "

　　In his reply, the Chairman of the Supreme Leader pointed out that the achievements in Sino-US relations are mainly attributed to the joint efforts of the two peoples. Sino-US relations continue to develop and need to rely more on the people of the two countries. Green, chairman of the US-China Aviation Heritage Foundation, deeply agrees with this. "Since the establishment of diplomatic relations, the exchanges between the United States and China in various fields have achieved fruitful results, and the depth and breadth of exchanges at all levels were unimaginable before the establishment of diplomatic relations. In the final analysis, the development of US-China relations is the result of the joint participation of the two peoples. " He said.

　　 "Gather more positive energy for the long-term development of US-China relations"

　　In his reply, the Chairman of the Supreme Leader emphasized that Chinese often said: Read thousands of books and take Wan Li Road. I announced that I would invite 50,000 American teenagers to exchange and study in China in the next five years, hoping that more American teenagers can visit China, observe China with their own eyes, listen to China with their own ears, measure China with their own steps, feel a real, three-dimensional and comprehensive China, and build more bridges between the two peoples.

　　The Chairman of the Supreme Leader attaches great importance to and personally promotes the friendly exchanges between Chinese and American people, and has repeatedly stressed that the future of Sino-US relations lies in the youth. In April, 2019, the Chairman of the Supreme Leader wrote back to the students of North niles High School in Illinois, USA, encouraging them to contribute to the friendship between the Chinese and American people. In August 2023, the Chairman of the Supreme Leader wrote back to the American-Chinese Youth Student Exchange Association in Washington State and friendly people from all walks of life, hoping that more Chinese and American youths would know each other and walk hand in hand, and become a new generation of ambassadors of friendship between the two countries, injecting momentum into the development of Sino-US relations. In November last year, the Chairman of the Supreme Leader announced in San Francisco that in order to expand the exchanges between the Chinese and American people, especially the younger generation, China would like to invite 50,000 American teenagers to exchange and study in China in the next five years.

　　Dennis Simon, a distinguished researcher at the Center for Sino-American Studies in the United States, said that China’s invitation to American teenagers to exchange and study in China will inject a strong impetus into the future development of US-China relations. "Youth exchange and educational exchange are important contents of humanities exchange, which will help more American students to understand China’s history, culture and domestic and foreign policies. When the younger generation grows up, it can continue to promote US-China cooperation and better work together to meet global challenges. " Simon said.

　　Luca Veron, a member of the board of directors of the Iowa Friendship Committee, said that US-China relations are the most important bilateral relations in the world. The two sides continue to strengthen exchanges and contacts and encourage young people to participate in them, which is conducive to the stable, healthy and sustainable development of US-China relations.

　　Taylor Lucas, a 19-year-old student from Muscatine, is very concerned that China will invite 50,000 American teenagers to China for exchange and study in the next five years. He said: "I have always been interested in China and hope to participate in the exchange and study program in China. I will study Chinese hard, and I will definitely take a walk and have a look in China when I have the chance. I believe that strengthening friendly exchanges between the youths of the two countries will bring more positive energy to the long-term development of US-China relations. "

　　 "Adhering to the concept of win-win cooperation is beneficial to both the United States and China and to the world."

　　In his reply, the Chairman of the Supreme Leader emphasized that China is willing to work with the United States to promote the stable, healthy and sustainable development of Sino-US relations, seek more benefits for the two peoples, provide more public goods for the international community, and jointly build a world of lasting peace, universal security, common prosperity, openness, tolerance and beauty.

　　Randy is very concerned about the development of US-China relations and hopes that both sides will work together to create well-being for the two peoples and contribute to world peace and development. She said: "Although there are some differences between the United States and China, the ties between the people are very strong. The two countries can seek common ground while reserving differences, expand consensus through dialogue and expand cooperation through deepening understanding. The stable, healthy and sustainable development of US-China relations is good for both sides and the world. "

　　Adam Foster, president of the helen foster snow Foundation in the United States, said that the Foundation is currently planning and organizing this year’s exchange activities between the United States and young people. "Both the United States and China are big countries with global influence, and the stable development of US-China relations is of vital importance to the world. The key is to conduct dialogue, manage differences and expand cooperation. Many global issues require the United States and China to work together and hope that both sides will develop bilateral relations in a constructive way. " Foster said.

　　"As the largest developed and developing country in the world, it is impossible for the United States and China not to deal with each other." Simon said, "The development of China has brought many opportunities to countries all over the world, including the United States. The United States and China can cooperate more in the fields of climate change, clean energy, global health and artificial intelligence. Looking at US-China relations with zero-sum thinking is not good for both sides. Adhering to the concept of win-win cooperation is beneficial to both the United States and China and to the world. "

　　Xinhua News Agency, Shijiazhuang, January 2 nd: Opening the door to the talents engine to empower the "city of the future" — — Interpretation of xiong’an new area Residence Permit Implementation Method and Points Settlement Method

　　Xinhua News Agency reporter Cao Guochang and Gao Bo

　　The xiong’an new area Municipal Management Committee recently officially issued the Implementation Measures for Residence Permit in xiong’an new area, Hebei Province (Trial) and the Measures for Settlement of Points in xiong’an new area, Hebei Province (Trial) (hereinafter referred to as the "two measures"). Since 2021, the residence permit and point settlement system have been tried out in xiong’an new area, which indicates that xiong’an new area has taken a solid step in deepening the reform of population management service system.

　　Both effective management and "high gold content"

　　The residence permit represents the acceptance and tolerance of the city to the foreign population. Holders of residence permits can enjoy basic public services such as local education, medical care, social security and accreditation, which fully reflects the fairness and inclusiveness of social construction.

　　What is the gold content of xiong’an new area residence permit? According to the measures for the implementation of residence permit in xiong’an new area, residence permit holders enjoy six basic services: compulsory education, basic public employment services, basic public health services and family planning services, public cultural and sports services, legal aid and other legal services, and other basic public services stipulated by the state and xiong’an new area. Enjoy seven conveniences: handling entry and exit documents in accordance with the relevant provisions of the state, renewing and replacing resident identity cards in accordance with the relevant provisions of the state, motor vehicle registration, applying for a motor vehicle driver’s license, signing up for vocational qualification examinations and applying for granting professional qualifications, handling birth service registration and other family planning certification materials, and other conveniences stipulated by the state and xiong’an new area.

　　Holding a residence permit in xiong’an new area can meet the basic needs of individuals to work and live in this city. It can be said that a "certificate" is in hand, and all the guarantees are available.

　　Anyone who has lived in xiong’an new area for more than half a year and has one of the conditions of legally stable employment, legally stable residence and continuous study can apply for a residence permit. What needs special explanation is that those who belong to Beijing’s non-capital function to relieve the transferred population are not restricted by the above conditions and can apply directly.

　　In addition, xiong’an new area implements the management system of residence permit points. When the holder’s residence permit score reaches the specified score, he can enjoy the corresponding public services such as housing security, old-age care, preschool education, and the corresponding convenience and welfare benefits. Those who meet the conditions for xiong’an new area points to settle down may apply to settle down in xiong’an new area.

　　The relevant person in charge of the xiong’an new area Management Committee said that the residence permit system and the points settlement system in xiong’an new area are to open the door to all kinds of talents needed during the large-scale development and construction of the new district to the greatest extent, so that they can "come, stay and develop well" and lay a solid talent foundation for the construction and development of the new district.

　　Experts believe that the vitality of the city depends on builders from all directions. xiong’an new area is now entering the stage of large-scale construction and industrial introduction, and implementing the residence permit system, so that the floating population can enhance their sense of belonging and identity with the local area, and the service management of the floating population can become a reality, which is exactly what Xiong ‘an needs to open its arms to attract talents from all walks of life.

　　Give priority to ensuring the function of Beijing’s non-capital and resolving population transfer

　　The Guiding Opinions on Supporting the Comprehensive Deepening of Reform and Opening-up in xiong’an new area, Hebei Province issued by the Central Committee of the Communist Party of China and the State Council pointed out that xiong’an new area should formulate a population transfer policy that is conducive to the relief of Beijing’s non-capital functions, establish a public service provision mechanism with residence permit as the carrier, and implement a point settlement system.

　　Compared with the points settlement and residence permit system in other cities in China, the "two measures" issued by xiong’an new area this time fully consider the gradual promotion of Beijing’s non-capital function to ease the transfer of population to xiong’an new area.

　　The relevant person in charge of the xiong’an new area Management Committee said that according to the relevant national policies and regulations on the reform and innovation of xiong’an new area’s household registration and population management system and the need to undertake the work of Beijing’s non-capital function relief, the "two measures" gave priority to the policy of Beijing’s non-capital function relief and transfer of population points and residence permits. The dual-track parallel mechanism of points settlement and talents settlement for Beijing’s non-capital functional relief transfer population is conducive to promoting the gathering of non-capital functional relief transfer population in xiong’an new area.

　　There is a separate chapter in the settlement method of xiong’an new area points, which clearly explains the situation of settlement points of Beijing’s non-capital function to ease the transfer population. Beijing household registration personnel of organs, organizations, enterprises and institutions that xiong’an new area undertakes to relieve and transfer Beijing’s non-capital functions, and their spouses and minor children who live together can apply to settle in xiong’an new area. If the non-Beijing household registration personnel of the organs, organizations, enterprises and institutions that the new district undertakes to relieve and transfer Beijing’s non-capital functions meet the standards for the identification of talents in Beijing, xiong’an new area, I and my spouse and minor children who live together may also apply to settle in xiong’an new area. Other non-Beijing household registration personnel of organs, organizations, enterprises and institutions that undertake the relief and transfer of Beijing’s non-capital functions in the new district may apply for settlement of points in accordance with the provisions of the Measures.

　　Leave enough "flexible space" for talents needed for urban development

　　In order to attract talents from all walks of life to take root in Xiong ‘an for innovation and entrepreneurship, orderly undertake the function relief of Beijing’s non-capital, reasonably control the population size and continuously optimize the population structure, non-local household registration personnel can apply for settlement in xiong’an new area in various ways.

　　According to the settlement method of xiong’an new area points, the settlement plan of points is not set, and will be adjusted according to the year, which is more flexible and possible. Xiong’an new area will implement the central government’s overall arrangement for the planning and construction of the new district and the pace of social and economic development, implement the requirements of the Hebei Provincial Party Committee and the provincial government, combine the actual situation of the support capacity such as infrastructure and public service level, and comprehensively consider the population size and structure of the new district to formulate the annual plan for the settlement of points. For industries and talents that meet the requirements of Beijing’s non-capital function relief and xiong’an new area’s special needs, a "special channel" for population management services will be opened.

　　The implementation of the "two measures" will be tried out. In the future, the settlement conditions, integral indicators, work procedures, certificate management and other aspects will be adjusted in combination with the actual construction and development of xiong’an new area, the changes in the specific demand for talents in the new district and the improvement of the conditions for handling public services in the new district, so that the household registration and population service management system can better meet the needs of high-quality construction and development in xiong’an new area.

　　It should be pointed out that the settlement of xiong’an new area points is a new settlement channel, which is implemented in parallel with other existing channels. The existing settlement channels in xiong’an new area mainly include: fresh graduates from xiong’an new area Shengyuan College and Technical Secondary School return to their original places, immediate family members take refuge, talents are introduced to settle down, etc. After the implementation of the settlement policy of points, other channels are still implemented according to the original policy.

　　Ambaviruzumab injection

　　Romisevir monoclonal antibody injection

　　● This is the first approved Covid-19 neutralizing antibody combination therapy drug with independent intellectual property rights in China.

　　● It can reduce the risk of hospitalization and death of COVID-19 patients with high clinical progression by 80%.

　　On July 7th, Tengshengbo Pharmaceutical and its holding company Tengsheng Huachuang announced that the combination therapy of COVID-19 neutralizing antibody Anbavir monoclonal antibody and Romisvir monoclonal antibody was commercialized in China, and the first batch of antibody drugs had been released commercially. This drug is also the first approved domestic COVID-19 neutralizing antibody combination therapy drug.

　　How effective is this COVID-19 specific medicine? Can ordinary families afford the cost of treatment? On July 8th, Luo Yongqing, president and general manager of Tengshengbo Pharmaceutical in Greater China, disclosed the pricing and production capacity of neutralizing antibody drugs in COVID-19.

　　Luo Yongqing said that overseas similar products generally adopt the mode of government procurement, and each person is in the range of 1,500-2,000 US dollars. The combination therapy of Tengsheng Bo Medicine will be priced within 10,000 yuan, which is lower than the global level.

　　It is reported that the first batch of thousands of medicines were sent to Shenzhen Third People’s Hospital. The next step will be to distribute the drugs to the whole country through three distributors: China Resources Medicine, Shanghai Medicine and Sinopharm Holdings.

　　Why are new drugs?

　　Pricing is so expensive?

　　According to reports, at present, the combination therapy of Ambroxobin and Romisvir is listed in China and adopts the independent pricing model. Overseas, the business model of the drug is the government procurement model. For example, if the US government purchases millions of people, the government procurement price for each person is between 1,500 and 2,000 US dollars. The domestic price of this specific drug made in COVID-19 is lower than the purchase price in the United States, basically within 10,000 RMB.

　　Luo Yongqing, President and CEO of Tengshengbo Pharmaceutical, revealed that the company invested more than US$ 200 million before and after the research and development of Anbavir monoclonal antibody and Romisvir monoclonal antibody to ensure the smooth development and commercialization. He said that the price of new drugs should comprehensively consider many factors such as dosage and pharmacoeconomic value. When Tengshengbo first designed the COVID-19 neutralizing antibody, it considered the possible mutation of the virus in the future, so it designed a pair of antibodies instead of one antibody.

　　"Our current dosage is 1000 mg of Ambavirumab plus 1000 mg of Romisvir, a total of 2,000 mg, which is the highest dosage among all approved neutralizing antibodies at home and abroad." Luo Yongqing said.

　　This specific medicine

　　Can I take medical insurance?

　　The price of this COVID-19 specific medicine is close to 10,000 yuan, which is a heavy burden for many low-income families. However, the good news is that patients can take medical insurance to settle accounts.

　　Since March 22 this year, several provincial and municipal medical insurance bureaus have successively included the combination therapy of Ambavirumab and Romisimab into the payment scope of local medical insurance funds. In contrast, another neutralizing antibody that has been approved for marketing in the world — — AstraZeneca Evusheld was also used in the pioneer area of international medical tourism in Boao Lecheng, Hainan this month through relevant policies. The indication is prevention before exposure of COVID-19, and the price of two injections at one time is 13,300 yuan, which cannot be settled by medical insurance.

　　In terms of production capacity, Tengshengbo Pharmaceutical said that it will make production plans according to the needs of domestic and foreign markets, and has reached cooperation with Yaoming Bio, a leading global biopharmaceutical contract development and production (CDMO) enterprise, which can match production capacity according to global and domestic epidemic prevention needs.

　　This new drug has been first used in Shenzhen Third People’s Hospital. At the same time, Tengshengbo Pharmaceuticals has entrusted three major distributors, namely China Resources Medicine, Sinopharm Holdings and Shanghai Pharmaceuticals. "They have the ability to cover any part of the country. Once there is demand, they can deliver it quickly. Coverage is not a problem." Luo Yongqing said.

　　After vaccination

　　Do you need a specific medicine?

　　At present, vaccines, small molecule drugs and neutralizing antibody drugs play different roles in COVID-19 epidemic response.

　　"Neutralizing antibodies can make up for the shortcomings faced by vaccines and small molecular drugs when used in immunocompromised people." Li Yan, chief medical officer of Tengshengbo Medicine, said that some people with weak immunity may not be suitable for COVID-19 vaccine, and even if they are vaccinated, they can’t produce enough antibodies because of their weak immune response, so the vaccine can’t play a preventive role. For this part of the population, injecting neutralizing antibody can produce "immediate" effect.

　　At present, Tengshengbo Pharmaceutical has received demand from more than 20 provinces and cities. However, the future market space of drugs mainly depends on the change of epidemic prevention policy and the influence of future epidemic evolution. "As BA.5 and BA.4 become the dominant Covid-19 (strain) overseas, it may also spread to China. I think this will create an application demand. " Luo Yongqing said.

　　According to national business daily and Beijing Daily client.

　　Special surprise

　　Double antibody+large dose

　　Studies have shown that it is effective for the "worst mutant"

　　On July 6th, WHO Director-General Tan Desai said that Omicron mutant strain BA.5 has been detected in 83 countries and regions, and BA.4 has been detected in 73 countries and regions. At present, BA.5 has replaced BA.2 as the main strain in the world. The latest weekly report on the global COVID-19 epidemic released by WHO shows that the number of COVID-19 cases in the world has increased for the fourth consecutive week, reaching the highest level since March this year.

　　Happily, the first domestic COVID-19 specific drug showed broad spectrum in the face of constantly changing viruses. "The results just obtained on the 7 th show that the combination therapy of Ambavirumab/Romisvir has shown a good virus inhibition effect on Omicron mutants BA.4 and BA.5." Lu Hongzhou, president of the Third People’s Hospital of Shenzhen, said that laboratory pseudovirus research shows that the antibody concentration required for the drug to inhibit 90% of BA.4 or BA.5 virus is very low, which can meet the effective standards set by the US Food and Drug Administration.

　　Zhang Linqi, the head of the R&D team and a professor at Tsinghua University Medical College, told reporters that everyone uses the method of screening "antibody pairs" to avoid virus escape, but they are particular about screening "antibody pairs". The two antibodies must cooperate with each other and be able to play a combination boxing, for example, to identify different positions of the virus. Based on the detailed study of the interaction process between virus and antibody, the team finally screened out the "antibody pair" that can inhibit the virus in time and space from 206 candidate antibodies and found the "best partner".

　　Luo Yongqing said that when the antibody was originally designed, the possible virus mutation in the future was considered, so it was not a single antibody, but a pair of antibodies; At the same time, considering the efficacy of the combination therapy, the dosage of "Anbavir monoclonal antibody (1000 mg)+Romisvir monoclonal antibody (1000 mg)" was finally determined, which is also the highest dose of neutralizing antibodies approved at home and abroad.

　　"Even if there are further virus mutations in the future, we can consider other methods, such as continuing to increase the dose to achieve the antiviral effect." Luo Yongqing said.