On January 8, at the Third Plenary Session of the 20th Central Commission for Discipline Inspection, General Secretary of the Supreme Leader delivered an important speech, referring to a strategic issue — —

　　"As the largest Marxist ruling party in the world, how can our party successfully jump out of the historical cycle rate of the rise and fall of chaos and ensure that the party will never deteriorate, change color and taste?"

　　The Communist Party of China (CPC) has been thinking and exploring how to jump out of the historical cycle rate of the rise and fall of chaos control.

　　In 1945, Comrade Mao Zedong gave the first answer in a cave dwelling in Yan ‘an, that is, "Only by letting the people supervise the government can the government dare not relax".

　　After a hundred years of struggle, especially the new practice since the 18th National Congress of the Communist Party of China, our party has given a second answer, which is to constantly promote the party’s self-revolution.

　　In the practice and theoretical exploration of comprehensively administering the Party strictly in the new era for ten years, our Party has continuously deepened its understanding of the Party’s self-revolution, accumulated rich practical experience, and formed a series of important theoretical achievements — —

　　On May 5, 2015, General Secretary of the Supreme Leader delivered an important speech at the twelfth meeting of the Central Leading Group for Comprehensively Deepening Reform, proposing self-revolution for the first time, emphasizing "being brave in self-revolution";

　　On July 1, 2016, at the celebration of the 95th anniversary of the founding of the Communist Party of China (CPC), the General Secretary of the Supreme Leader emphasized that "the whole party should use the political courage of self-revolution to focus on solving the outstanding problems existing in the party itself and constantly enhance the party’s self-purification, self-improvement, self-innovation and self-improvement ability";

　　On October 25, 2017, when The Politburo Standing Committee (PSC), the 19th CPC, met with Chinese and foreign journalists, General Secretary of the Supreme Leader declared: "Practice has fully proved that the Communist Party of China (CPC) can lead the people to carry out a great social revolution and a great self-revolution";

　　In January 2018, at the opening ceremony of the seminar on studying and implementing the spirit of the 19th National Congress of the Communist Party of China, the General Secretary of the Supreme Leader put forward "four difficulties" to alert the whole party, emphasizing that "to carry out the great social revolution of Socialism with Chinese characteristics in the new era, our party must be brave in self-revolution and build the party stronger";

　　In January 2019, the General Secretary of the Supreme Leader proposed at the Third Plenary Session of the 19th Central Commission for Discipline Inspection that "the continuous self-revolution while carrying out social revolution is the most remarkable sign that our party is different from other political parties, and it is also the key for our party to move from victory to new victory";

　　In January 2020, at the Fourth Plenary Session of the 19th Central Commission for Discipline Inspection, the General Secretary of the Supreme Leader highly summarized the important experience of "persisting in leading the great social revolution with great self-revolution" since the 18th CPC National Congress, which provided important follow-up for deepening the party’s self-revolution in the new era and promoting the comprehensive and strict management of the party.

　　In November, 2021, the Sixth Plenary Session of the 19th CPC Central Committee deliberated and adopted the third historical resolution of the Party, and listed "persisting in self-revolution" as one of the ten historical experiences of the Party’s century-long struggle.

　　On January 18, 2022, at the Sixth Plenary Session of the 19th Central Commission for Discipline Inspection, General Secretary of the Supreme Leader profoundly summarized the successful practice of the Party’s self-revolution in the new era, and expounded the regular understanding of "nine persistences" and the principled requirements of "six musts";

　　On October 16, 2022, the Party’s Report to the 20th CPC National Congress put forward that "we must always be sober and firm in solving the unique problems of the big party" and "strictly administering the party in an all-round way is always on the road, and the party’s self-revolution is always on the road";

　　… … … …

　　At this plenary session, the General Secretary of the Supreme Leader summed up the new progress and new achievements of strictly administering the Party in an all-round way, profoundly expounded the important thought of the Party’s self-revolution, and scientifically answered three major questions: why our Party should self-revolution, why it can self-revolution, and how to promote it.

　　Why self-revolution?

　　Advanced Marxist political parties are not born, but are tempered by constant self-revolution. General Secretary of the Supreme Leader stressed: "Under the new historical conditions, the key to maintaining the true nature of the party’s Marxist political party forever depends on our party itself."

　　The 20th National Congress of the Communist Party of China drew a grand blueprint for building a socialist modernization power in an all-round way and promoting the great rejuvenation of the Chinese nation in an all-round way with Chinese modernization, which sounded the clarion call of the times for a new journey of endeavor.

　　The new historical mission brings new examination questions of the times — —

　　Looking at the world, the great changes that have never happened in a hundred years have accelerated their evolution, and the world has entered a new period of turbulent change. The changes of the world, the times and the history are unfolding in an unprecedented way;

　　Looking at the national conditions, China’s reform, development and stability are faced with many deep-seated contradictions that cannot be avoided or circumvented. China’s development has entered a period in which strategic opportunities and risk challenges coexist and uncertain and unpredictable factors increase;

　　Examining the party’s situation, the test of governance, reform and opening up, market economy and external environment that the party faces will exist for a long time, and the danger of mental slack, lack of ability, separation from the masses and negative corruption will exist for a long time.

　　The heavier the task, the greater the risk test, and the more we should carry forward the spirit of self-revolution.

　　On the new journey, Do not forget your initiative mind’s mission is to be brave in self-revolution, constantly remove all harmful factors that damage the Party’s advanced nature and purity, and constantly remove all pathogens that erode the Party’s healthy body, so as to ensure that the Party will not deteriorate, change color and taste, and always become the most reliable backbone of all the people.

　　Why can you self-revolution?

　　Not private, but the world is public.

　　In February 2017, the General Secretary of the Supreme Leader emphasized at the opening ceremony of the seminar for leading cadres at the provincial and ministerial levels to study and implement the spirit of the Sixth Plenary Session of the Eighteenth Central Committee that our party has the courage of self-revolution because our party has no special interests of its own except the interests of the country, the nation and the people.

　　Facing the key minority, the Supreme Leader General Secretary expounded the relationship between selflessness and self-revolution — —

　　"If you don’t seek personal gain, you can seek the root and profit, and you can examine yourself from the nature and fundamental purpose of the party and the fundamental interests of the people; In order not to hide shortcomings, avoid problems, whitewash mistakes, overcome shortcomings, solve problems, admit mistakes and correct mistakes. "

　　In November 2021, at the second plenary session of the Sixth Plenary Session of the 19th CPC Central Committee, the General Secretary of the Supreme Leader pointed out: "Our party does not have any special interests of its own, which is the source of our party’s courage and confidence in self-revolution."

　　"It is precisely because of selflessness that we can always examine ourselves and think about ourselves in the spirit of thorough materialism, and we can get rid of the hunting and corrosion of all interest groups, powerful groups and privileged classes, and open our eyes to those who are trapped by these groups, groups and classes in the party." General Secretary of the Supreme Leader stressed.

　　Politics is selfish. If you don’t seek self-interest, you can seek the root and profit.

　　The nature and purpose of the Party and its initial mission determine that our Party always represents the fundamental interests of the overwhelming majority of the people in China, and shares weal and woe with the people.

　　How to promote self-revolution?

　　Facing new problems and challenges, the General Secretary of the Supreme Leader warned the whole party: "Managing the Party and the Party cannot be relaxed for a moment, and we must always grasp it unremittingly and firmly, and we must never feel relaxed and tired of fighting. We must persevere in comprehensively and strictly administering the Party, deepen the new great project of Party building in the new era, and lead the social revolution with the party’s self-revolution."

　　At this plenary session, the important task of promoting self-revolution was anchored, and it was highlighted that nine issues need to be grasped in deepening the party’s self-revolution practice — —

　　To adhere to the centralized and unified leadership of the CPC Central Committee as the fundamental guarantee;

　　To lead the great social revolution as the fundamental purpose;

　　Follow Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era;

　　Taking jumping out of the historical cycle rate as the strategic goal;

　　To solve the unique problems of the big party as the main direction;

　　To improve the comprehensive and strict management of the party system as an effective way;

　　Taking forging a strong organization and building an excellent team as an important focus;

　　Taking the fight against corruption as an important starting point;

　　The combination of self-supervision and people’s supervision is a powerful driving force.

　　The practical requirements of "Nine Actions" provide a scientific action guide for continuing to promote the Party’s self-revolution on the new journey.

　　In the new journey, we should accurately grasp the practical requirements of the "Nine Perspectives", make the Party’s ideas and measures of self-revolution more rigorous, make the self-revolution on every front and every link concrete and thorough, and carry it through to the end, so that we will surely hand over new and more excellent answers on the new road of rushing to the exam.

　　Planning: Zhang Yi Du Shangze

　　Written by Zhao Cheng

　　Editor: Han Yan

　　Proofreading: Julie

　　Photo: Xinhua News Agency reporter Ju Peng

　　Vision: Bi Xiaoyang and Yu Dongsheng

　　Ambaviruzumab injection

　　Romisevir monoclonal antibody injection

　　● This is the first approved Covid-19 neutralizing antibody combination therapy drug with independent intellectual property rights in China.

　　● It can reduce the risk of hospitalization and death of COVID-19 patients with high clinical progression by 80%.

　　On July 7th, Tengshengbo Pharmaceutical and its holding company Tengsheng Huachuang announced that the combination therapy of COVID-19 neutralizing antibody Anbavir monoclonal antibody and Romisvir monoclonal antibody was commercialized in China, and the first batch of antibody drugs had been released commercially. This drug is also the first approved domestic COVID-19 neutralizing antibody combination therapy drug.

　　How effective is this COVID-19 specific medicine? Can ordinary families afford the cost of treatment? On July 8th, Luo Yongqing, president and general manager of Tengshengbo Pharmaceutical in Greater China, disclosed the pricing and production capacity of neutralizing antibody drugs in COVID-19.

　　Luo Yongqing said that overseas similar products generally adopt the mode of government procurement, and each person is in the range of 1,500-2,000 US dollars. The combination therapy of Tengsheng Bo Medicine will be priced within 10,000 yuan, which is lower than the global level.

　　It is reported that the first batch of thousands of medicines were sent to Shenzhen Third People’s Hospital. The next step will be to distribute the drugs to the whole country through three distributors: China Resources Medicine, Shanghai Medicine and Sinopharm Holdings.

　　Why are new drugs?

　　Pricing is so expensive?

　　According to reports, at present, the combination therapy of Ambroxobin and Romisvir is listed in China and adopts the independent pricing model. Overseas, the business model of the drug is the government procurement model. For example, if the US government purchases millions of people, the government procurement price for each person is between 1,500 and 2,000 US dollars. The domestic price of this specific drug made in COVID-19 is lower than the purchase price in the United States, basically within 10,000 RMB.

　　Luo Yongqing, President and CEO of Tengshengbo Pharmaceutical, revealed that the company invested more than US$ 200 million before and after the research and development of Anbavir monoclonal antibody and Romisvir monoclonal antibody to ensure the smooth development and commercialization. He said that the price of new drugs should comprehensively consider many factors such as dosage and pharmacoeconomic value. When Tengshengbo first designed the COVID-19 neutralizing antibody, it considered the possible mutation of the virus in the future, so it designed a pair of antibodies instead of one antibody.

　　"Our current dosage is 1000 mg of Ambavirumab plus 1000 mg of Romisvir, a total of 2,000 mg, which is the highest dosage among all approved neutralizing antibodies at home and abroad." Luo Yongqing said.

　　This specific medicine

　　Can I take medical insurance?

　　The price of this COVID-19 specific medicine is close to 10,000 yuan, which is a heavy burden for many low-income families. However, the good news is that patients can take medical insurance to settle accounts.

　　Since March 22 this year, several provincial and municipal medical insurance bureaus have successively included the combination therapy of Ambavirumab and Romisimab into the payment scope of local medical insurance funds. In contrast, another neutralizing antibody that has been approved for marketing in the world — — AstraZeneca Evusheld was also used in the pioneer area of international medical tourism in Boao Lecheng, Hainan this month through relevant policies. The indication is prevention before exposure of COVID-19, and the price of two injections at one time is 13,300 yuan, which cannot be settled by medical insurance.

　　In terms of production capacity, Tengshengbo Pharmaceutical said that it will make production plans according to the needs of domestic and foreign markets, and has reached cooperation with Yaoming Bio, a leading global biopharmaceutical contract development and production (CDMO) enterprise, which can match production capacity according to global and domestic epidemic prevention needs.

　　This new drug has been first used in Shenzhen Third People’s Hospital. At the same time, Tengshengbo Pharmaceuticals has entrusted three major distributors, namely China Resources Medicine, Sinopharm Holdings and Shanghai Pharmaceuticals. "They have the ability to cover any part of the country. Once there is demand, they can deliver it quickly. Coverage is not a problem." Luo Yongqing said.

　　After vaccination

　　Do you need a specific medicine?

　　At present, vaccines, small molecule drugs and neutralizing antibody drugs play different roles in COVID-19 epidemic response.

　　"Neutralizing antibodies can make up for the shortcomings faced by vaccines and small molecular drugs when used in immunocompromised people." Li Yan, chief medical officer of Tengshengbo Medicine, said that some people with weak immunity may not be suitable for COVID-19 vaccine, and even if they are vaccinated, they can’t produce enough antibodies because of their weak immune response, so the vaccine can’t play a preventive role. For this part of the population, injecting neutralizing antibody can produce "immediate" effect.

　　At present, Tengshengbo Pharmaceutical has received demand from more than 20 provinces and cities. However, the future market space of drugs mainly depends on the change of epidemic prevention policy and the influence of future epidemic evolution. "As BA.5 and BA.4 become the dominant Covid-19 (strain) overseas, it may also spread to China. I think this will create an application demand. " Luo Yongqing said.

　　According to national business daily and Beijing Daily client.

　　Special surprise

　　Double antibody+large dose

　　Studies have shown that it is effective for the "worst mutant"

　　On July 6th, WHO Director-General Tan Desai said that Omicron mutant strain BA.5 has been detected in 83 countries and regions, and BA.4 has been detected in 73 countries and regions. At present, BA.5 has replaced BA.2 as the main strain in the world. The latest weekly report on the global COVID-19 epidemic released by WHO shows that the number of COVID-19 cases in the world has increased for the fourth consecutive week, reaching the highest level since March this year.

　　Happily, the first domestic COVID-19 specific drug showed broad spectrum in the face of constantly changing viruses. "The results just obtained on the 7 th show that the combination therapy of Ambavirumab/Romisvir has shown a good virus inhibition effect on Omicron mutants BA.4 and BA.5." Lu Hongzhou, president of the Third People’s Hospital of Shenzhen, said that laboratory pseudovirus research shows that the antibody concentration required for the drug to inhibit 90% of BA.4 or BA.5 virus is very low, which can meet the effective standards set by the US Food and Drug Administration.

　　Zhang Linqi, the head of the R&D team and a professor at Tsinghua University Medical College, told reporters that everyone uses the method of screening "antibody pairs" to avoid virus escape, but they are particular about screening "antibody pairs". The two antibodies must cooperate with each other and be able to play a combination boxing, for example, to identify different positions of the virus. Based on the detailed study of the interaction process between virus and antibody, the team finally screened out the "antibody pair" that can inhibit the virus in time and space from 206 candidate antibodies and found the "best partner".

　　Luo Yongqing said that when the antibody was originally designed, the possible virus mutation in the future was considered, so it was not a single antibody, but a pair of antibodies; At the same time, considering the efficacy of the combination therapy, the dosage of "Anbavir monoclonal antibody (1000 mg)+Romisvir monoclonal antibody (1000 mg)" was finally determined, which is also the highest dose of neutralizing antibodies approved at home and abroad.

　　"Even if there are further virus mutations in the future, we can consider other methods, such as continuing to increase the dose to achieve the antiviral effect." Luo Yongqing said.